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Alcohol Skin Flush

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Background

Alcohol flush reaction is a condition in which individuals, following consumption of alcohol, develop a reddening of the skin on the face, upper body, and in some cases the whole body. It is colloquially known as "Asian Flush" or "Asian Blush" due to the fact that a significant portion of East Asians (Korean, Japanese, and Chinese) experience this physical reaction.1 The cause of these symptoms comes from genetic differences in a breakdown enzyme known as dehydrogenase — those affected with the condition carry a variant that speeds up the breakdown of alcohol into a toxic byproduct known as acetaldehyde. Acetaldehyde is responsible for the physical manifestation of skin blotchiness/reddness.2

Did you know?

Those that carry the ALDH2 enzyme variant, i.e. those who experience alcohol flush reaction, on average are less likely to suffer from alcoholism as a result of the negative physical effects of consuming alcohol.2

Where does this Genome App look?

This analysis looks at your genetic information presented at the rs671 single-nucleotide polymorphism — located on the ALDH2 gene of chromosome 12.3

Medical Disclaimer

Your results and genetic information from this analysis are not intended to be a substitute for professional medical advice, diagnoses, and treatment. The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to diagnose, treat, cure, or prevent any disease and all medical-related inquiries should be reviewed with a professional licensed healthcare provider.

Sources
1. Brooks, Philip J., et al. "The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption." PLoS medicine 6.3 (2009): e1000050.
2. Peng, Yi, et al. "The ADH1B Arg47His polymorphism in East Asian populations and expansion of rice domestication in history." BMC evolutionary biology 10.1 (2010): 15.

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