Tzourio-Mazoyer, N., Labache, L., Zago, L., Hesling, I., & Mazoyer, B. (2021). Neural support of manual preference revealed by BOLD variations during right and left finger-tapping in a sample of 287 healthy adults balanced for handedness. Laterality, 26(4), 398-420. DOI: 10.1080/1357650X.2020.1862142
In the line of the SENSAAS and WMCA atlases that are atlases that have bee proposed to the community on the networks dedicated to sentence and word-list processing, the 13 hands regions that have been selected and described in the present work are available as an atlas.
HAMOTA, HAnd MOtor Area atlas, is a brain atlas aimed to investigate the anatomo-functional support of handedness (manual preference).
To complete this investigation, a sample of 287 individuals have been analyzed (balanced for handedness and sex). Each participant completed both a Right Finger Tapping task (RFT) and a Left Finger Tapping task (LFT). In order to identify areas whose activity was dependent on the moving hand, we selected the cortical and the subcortical regions showing activation and asymmetry favoring the hemisphere contralateral to the moving hand during both the LFT and RFT, in right- and left-handers. The cerebellar regions showed ipsilateral activation and asymmetry, during both the LFT and RFT, also have been included. 13 regions were selected, including the primary and secondary sensorimotor, and premotor cortices, thalamus, dorsal putamen and cerebellar lobule IV.
The Atlas folder contains 4 files:
read_me_HAMOTA.rtf: README file containing information about the atlasHAMOTA_MNI_ICBM_152_2mm.nii.gz: NIfTI file containing the 13 brain regions in the MNI space
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HAMOTA_description.csv: CSV file containing a full description of each areas. The first column (Index) correspond to the index of each region that is used in the NIfTI file. The second column (ROI) is the anatomical labels of each regions. Finaly, the MNI coordinate (columns Xmm, Ymm, Zmm) of each regions centroid is provided. -
template_ANTs_80tvs_on_MNI.nii.gz: brain template used to align the atlas on, provided in MNI stereotaxic space (MNI ICBM 152, Template sampling size of 2x2x2 mm3 voxels; bounding box, x = -90 to 90 mm, y = -126 to 91 mm, z = -72 to 109 mm)
Location of the 13 regions showed in the left hemisphere. (A) Comparison with the map of the main effect of all finger-tapping tasks in the meta-analysis conducted by Witt et al, 2008. The ALE maps are shown side to side with the regions of the present atlas that are labelled on axial slices of the left hemisphere and right cerebellum (B) Comparison with the regions involved in the motor network for hand movements as explored with intrinsic connectivity by Newbold and colleagues together with lateral left hemisphere presentation of the 13 areas of the present work.
Importantly, the neural support of handedness is complex and does not rely on a mirrored organization of the activity in contralateral motor cortices associated with preferred hand movement between rigt-handers and left-handers.
The Data folder contains 2 files:
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Data_HAMOTA_TzourioMazoyer2021.csv: this dataset has been generated from a subsample of 287 participants (143 left-handers) from the BIL&GIN database. The dataset contains age, sex, self-reported manual preference (handedness) and Edinburgh score, for each participant. It also includes measures of frequencies (in Hz) when particpants performed self-paced right and left finger tapping tasks during an fMRI experiment. fMRI task-induced BOLD-signal variations and left minus asymmetry during right and left FTT have been computed in the regions of the AICHA atlas. The dataset contains BOLD signal variations in the 13 pairs of regions during left and right FTT, as well as several contrast between these BOLD variations (asymmetries, difference between dominant and minor hand, differences between LFT and RFT). -
readMe_data_HAMOTA.csv: full description of each columns of the above dataset.
- SEntence Supramodal Areas AtlaS: SENSAAS
- Word-list Multimodal Cortical Atlas: WMCA
- Atlas of Lateralized visuospatial Attentional Networks: ALANs
- Atlas of Intrinsic Connectivity of Homotopic Areas: AICHA
Please contact me (Loïc Labache) as loic.labache@yale.edu and/or loic.labache@ensc.fr