I am a neuroscience PhD candidate studying in the Epp Lab in the Hotchkiss Brain Institute at the University of Calgary.
- My primary academic interest is studying the brain-wide dynamics supporting learning and memory
- My prefered techniques for these investigations include (but are not limited to - I'm always looking out for new techniques!):
- Batteries of sophisticated behavioural analyses
- Brain-wide mapping of immediate early gene expression and the graph theoretical analysis of these functional connectivity networks
- In vivo monitoring of cell type specific activity in specific target regions, at both a single cell level and at the level of regional population activity
- Advanced histology and microscopy techniques, including various tissue clearing approaches, and sophisticated analysis of these images
- 3D CAD modelling and the prototyping of scientific hardware
- My prefered techniques for these investigations include (but are not limited to - I'm always looking out for new techniques!):
- Image Registration to Custom Atlases as per https://doi.org/10.1523/ENEURO.0325-21.2022
- Fibre Photometry Analyses as per https://doi.org/10.1101/2022.08.19.504565
- GitHub Repositories with the code used for data analysis (when applicable).
- Further information on these publications can be found at the linked profiles (click icons):
| Directory | Title | Included Analyses |
|---|---|---|
| Scott, Terstege, Vu 2020 | Disrupted Neurogenesis in Germ-Free Mice: Effects of Age and Sex | N/A |
| Scott 2021 | Adult neurogenesis mediates forgetting of multiple types of memory in the rat | N/A |
| Terstege 2021 | Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test | N/A |
| Evans Terstege 2022 | Neurogenesis mediated plasticity is associated with reduced neuronal activity in CA1 during context fear memory retrieval | #photometry #FASTMAP |
| Terstege 2022A | Brain-wide neuronal activation and functional connectivity are modulated by prior exposure to repetitive learning episodes | #wholebrain #pointmask #targeteddeletion |
| Terstege 2022B | FASTMAP: Open-Source Flexible Atlas Segmentation Tool for Multi-Area Processing of Biological Images | #FASTMAP |
| Terstege 2022C | New neurons in old brains: implications of age in the analysis of neurogenesis in post-mortem tissue | N/A |
| Terstege 2022D | Network neuroscience untethered: brain-wide immediate early gene expression for the analysis of functional connectivity in freely behaving animals | #wholebrain #pointmask #wholebrainanalysis |
| Moretti Terstege 2022 | Low intensity repetitive transcranial magnetic stimulation modulates brain-wide functional connectivity to promote anti-correlated activity | #wholebrain #pointmask #wholebrainanalysis #labelcoexpression #FASTMAP |
| Dawson 2022 | Sex-dependent role of hypocretin/orexin neurons in social behavior | #photometry |
| Terstege 2023A | Sex-dependent impairments of parvalbumin expressing neurons in the retrosplenial cortex in Alzheimer’s disease | #wholebrain #pointmask #wholebrainanalysis #photometry |
| Terstege 2023B | Protocol for the integration of fiber photometry and social behavior in rodent models | #photometry |
| Terstege 2023C | Parvalbumin as a sex-specific target in Alzheimer’s disease research – A mini-review | N/A |
| Terstege 2023D | PAW, a cost-effective and open-source alternative to commercial rodent running wheels | #PAW |
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Always open to collaboration on the following kinds of problems
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Work automating and quantifying histology
- Brain-wide regional label expression
- Colocalization of fluorescent labels in 3D volumetric imaging sets
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The analysis of time-course datasets
- multi/single region fibre photometry
- multi/single region fibre photometry
- miniscope recordings
- mesoscale imaging data
- fMRI (human and rodent)
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I am happy to answer any questions concerning the analyses included on my GitHub profile.
