dssp_parser by: Andrea Rubbi

Python program which is able to analyze dssp files in order to estimate the interacting area and interacting residues between monomers of a complex protein

This program is part of a larger project whose aim is to analyze the Hemoglobin complex and its components. It is written in python and it is quite easy to use:

How to use it:

run the program using: $ ./dssp_parser.py

It will then ask you some info: chain of interest --> input on terminal dssp of a trimer with the selected chain --> input by selecting a file from the automatically opened window dssp of the tetramer --> same as above

Then it asks whether you would like to analyze the interacting surface with the tetramer or with the trimer --> 'r' for trimer / 'e' for tetramer

It asks whether you would like to calculate the total accessible area of the chain in the complex --> 'y' to calculate it

Finally:

It asks whether you would like to calculate the relative accessible area of the chain both in the tatramer and in the trimer

It also reports a table with all the residues with a significantly changing accessible area with respect to the chain in the trimer or in the tetramer

After that it asks whether you would like to analyze another interaction or not.

Requirements:

-- colored --> python3 -m pip install colored -- numpy--> python3 -m pip install numpy -- easygui --> python3 -m pip install easygui -- pandas --> python3 -m pip install pandas