diff --git a/packaging/python/build_requirements.txt b/packaging/python/build_requirements.txt
index dcbd639f9c..ffb508170f 100644
--- a/packaging/python/build_requirements.txt
+++ b/packaging/python/build_requirements.txt
@@ -1,2 +1,4 @@
 cython<3
 packaging
+build
+setuptools_scm
diff --git a/packaging/python/build_wheels.bash b/packaging/python/build_wheels.bash
index 007fa581ce..0c6cab0f10 100755
--- a/packaging/python/build_wheels.bash
+++ b/packaging/python/build_wheels.bash
@@ -103,7 +103,18 @@ build_wheel_linux() {
     # Workaround for https://github.com/pypa/manylinux/issues/1309
     git config --global --add safe.directory "*"
 
-    python setup.py build_ext --cmake-prefix="/nrnwheel/ncurses;/nrnwheel/readline" --cmake-defs="$CMAKE_DEFS" $setup_args bdist_wheel
+    if [ -n "${setup_args}" ]; then
+        python -m build --wheel --no-isolation \
+            --config-setting="--global-option=build_ext" \
+            --config-setting="--global-option=${setup_args}" \
+            --config-setting="--global-option=--cmake-defs=${CMAKE_DEFS}" \
+            --config-setting='--global-option=--cmake-prefix="/nrnwheel/ncurses;/nrnwheel/readline"'
+    else
+        python -m build --wheel --no-isolation \
+            --config-setting="--global-option=build_ext" \
+            --config-setting="--global-option=--cmake-defs=${CMAKE_DEFS}" \
+            --config-setting='--global-option=--cmake-prefix="/nrnwheel/ncurses;/nrnwheel/readline"'
+    fi
 
     # For CI runs we skip wheelhouse repairs
     if [ "$SKIP_WHEELHOUSE_REPAIR" = true ] ; then
@@ -175,7 +186,18 @@ build_wheel_osx() {
       fi
     fi
 
-    python setup.py build_ext --cmake-prefix="/opt/nrnwheel/ncurses;/opt/nrnwheel/readline;/usr/x11" --cmake-defs="$CMAKE_DEFS" $setup_args bdist_wheel
+    if [ -n "${setup_args}" ]; then
+        python -m build --wheel --no-isolation \
+            --config-setting="--global-option=build_ext" \
+            --config-setting="--global-option=${setup_args}" \
+            --config-setting="--global-option=--cmake-defs=${CMAKE_DEFS}" \
+            --config-setting='--global-option=--cmake-prefix="/opt/nrnwheel/ncurses;/opt/nrnwheel/readline;/usr/x11"'
+    else
+        python -m build --wheel --no-isolation \
+            --config-setting="--global-option=build_ext" \
+            --config-setting="--global-option=--cmake-defs=${CMAKE_DEFS}" \
+            --config-setting='--global-option=--cmake-prefix="/opt/nrnwheel/ncurses;/opt/nrnwheel/readline;/usr/x11"'
+    fi
 
     echo " - Calling delocate-listdeps"
     delocate-listdeps dist/*.whl