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Goal: I am just trying to generate some extra information to interpret/filter my smaller deletions, insertions and duplications. If you have a better idea, please let me know.
--by just tells mosdepth that you want extra information for those regions or that region. But it must still read the entire chromosome. It's built to be fast on whole-file operations, not on select regions.
I think you can use duphold along with visual plots to evaluate smaller deletions. Duphold will be less reliable the smaller the event, but there should still be signal.
I just wanted to try mosdepth on some of my smaller deletions:
mosdepth --by <(echo -e "chr1\11869\t12227") mosdepth-test-out --d4 -t 4 -f $FASTA $BAMFILE
The command takes for ages. Do you know why?
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